The adrenal glands are 2 small, pyramidal shaped glands atop the kidneys. They perform numerous important functions for the body, and consist of two main parts, the medulla and the cortex. The adrenal medulla responds to acute stress and produces epinephrine and norepinephrine. The adrenal cortex responds to physical/emotional stress and infection. The pituitary hormone ACTH (adrenocorticotropic hormone) is released as a result of stress and it governs adrenal cortex function. The cortex produces cortisol, aldosterone, and the androgens testosterone, DHEA, and androstenedione.

Adrenal Glandular Plus by Nutritional Frontiers aims to support adrenal gland function by providing key nutrients used by the adrenal glands, along with glandular therapy.* Glandular-derived medicines were commonly used in Western medicine before synthetic pharmaceuticals became widely available.

This unique, SPM omega-3 derived supplement was designed to help modulate and resolve inflammation. SPM stands for "Specialized Pro-resolving Mediators" which are recently discovered, naturally occurring substances derived from omega-3 and omega-6 fatty acids. Our bodies make SPMs as a response to help resolve inflammation and they can be produced all over the body in areas like the bloodstream, nervous system tissue, and breastmilk. Specialized pro-resolving mediators are theorized to contribute to the demonstrable beneficial effects of omega-3 fatty acids on reducing inflammation.

The inflammatory process consists of a chain of events in response to trauma or injury. Inflammation may be acute or chronic and leads to changes in the tissues, cells, and blood vessels surrounding the inflamed area. While acute inflammation is a necessary and important response to trauma or injury, ongoing inflammation is associated with many disease conditions such as arthritis, autoimmune diseases, cardiovascular disease, asthma, Crohn’s disease and ulcerative colitis, and more. Furthermore, the medical community now understands that uncontrolled inflammation is involved in the pathogenesis of many diseases not previously categorized as inflammatory, such as Alzheimer’s disease, Parkinson’s disease, and cancer.

SPMs do not block the vital initial inflammatory response to trauma, but rather SPMs prevent excessive inflammation and promote tissue homeostasis (return to normal functioning) by controlling the duration and magnitude of inflammation. They are called ‘resolving mediators’ because of their role in facilitating natural resolution of the inflammatory response. Examples of SPMs include resolvins, lipoxins, protectins, and maresins. SPMs have demonstrated potent immunoregulatory and anti-inflammatory activities such as inhibiting the production of pro-inflammatory mediators and regulating white blood cells. In addition to actively resolving inflammation, SPMs protect organs and stimulate tissue regeneration.

Research shows that SPM levels in the body are associated with reduced pain scores in patients with knee arthritis. Furthermore, erythrocyte sedimentation rates (ESR), a blood test marker for inflammation, were also reduced in those patients with arthritis taking SPM. Many animal studies demonstrate improved healing rates in conditions like colitis, ischemic kidney damage, periodontitis, and asthma.

While SPMs are produced naturally in humans, the ability of the body to produce SPMs may be compromised in the setting of obesity and aging. Since SPMs are involved in the active, regulated process of resolving acute inflammation and managing the return to tissue homeostasis, supplementing with SPMs may provide benefit and relief to those individuals struggling with discomfort and prolonged inflammation.*

Melatonin Spray is a dietary supplement to support normal sleep. Melatonin is the principle hormone produced and secreted by the brain’s pineal gland and is responsible for maintaining circadian rhythm (the body’s biological clock), regulating the endocrine (hormone) system and supporting the immune system. At night, the secretion of melatonin is much higher than during the day. When this process is interrupted, certain symptoms can occur such as disruptions in the sleep/wake cycle, headaches, mental and physical fatigue and irritability.

Liposomal Delivery System
A liposomal liquid delivery system allows for flexible, convenient dosing of Melatonin in order to address individual requirements. Liposomal technology helps to maintain the health benefits of Melatonin by protecting it from the degradative environment of the stomach. This is especially beneficial for patients who have had gastric bypass or general gastro-intestinal dysfunction. Liposomal encapsulation of ingredients represents a new delivery system that appears to offer important advantages over existing methods of delivery. Recommended for:

• Sleep support
• Antioxidant and immune system support
• Balanced circadian rhythms important for recovery from jet-lag and rotating shift work
• Mood Balance

Why is Melatonin important?
Low levels of melatonin could result in poor sleep patterns, low mood, delayed sleep phase syndrome, insomnia associated with attention deficit hyperactivity disorder, irritability, learning disorders, poor concentration, seasonal affective disorder, menstrual disturbances and headaches.

Sleep Quality
Melatonin plays an important role in when we fall asleep and when we wake up. Darkness stimulates the release of melatonin and light suppresses its activity. Normal melatonin cycles are disrupted when we are exposed to excessive light in the evening or too little light during the daytime. Melatonin supports sleep onset and quality of sleep and increased Rapid Eye Movement time, deep sleep and dreaming. These changes demonstrate better quality sleep, which produces greater mental, physical and emotional rejuvenation. Melatonin can decrease the amount of time required to fall asleep, increase the number of sleeping hours and support daytime alertness.

Jet Lag and Rotating Shift Work
Jet lag and rotating shift work can interfere with the body’s natural circadian rhythm. Melatonin supports quality sleep and balanced circadian rhythms in people with disrupted circadian rhythms (such as those suffering from jet lag or poor vision or those who work the night shift) and those with low melatonin levels (such as some elderly).

Menopause Support
Melatonin is also one of the hormones that controls the timing and release of female reproductive hormones. It helps determine when menstruation begins, the frequency and duration of menstrual cycles, and when menopause begins. It’s a powerful regulator of sex hormone production and can affect mood, immunity, reproduction and bone health. Melatonin supplements may benefit menopausal women by supporting and sustaining sleep and by supporting osteoblasts that support bone health.

Immune and Antioxidant Support
Melatonin has strong antioxidant properties and helps support immune system strength. As an antioxidant it is six to ten times more potent than vitamin E, and is one of the few antioxidants that can enter the mitochondria to protect it from free radical damage.

Mood Support Some people experience a depressed mood when low sunlight levels (winter) are not sufficient for their pineal glands to decrease melatonin production to its normal low daytime level. Melatonin supplementation can support mood balance seasonally or in times of low mood.

Mag Complete 300 is a dietary supplement providing 3 important chelated forms of magnesium for enhanced absorption.*

Magnesium deficiencies have been associated with a variety of conditions such as:

• Confusion*
• Occasional sleeplessness*
• Low mood states*
• Irritability*
• Fatigue*
• Musculoskeletal conditions*
• Tooth decay*

What are Chelates? Chelates are organic compounds attached to a mineral resulting in a stable structure. The purpose of chelated minerals is to surround a metal ion with an organic molecule so that it can be better absorbed in the human body.

About Magnesium:

Magnesium is an essential mineral. It must be taken in through the diet however; with over processed food and depleted soil it is difficult to get the optimal daily intake. Magnesium supplementation is a way to support your daily intake.

Magnesium promotes the absorption and metabolism of calcium and is responsible for the activation and function of 325 enzymes that affect various metabolic processes and physiological functions such as:

- Neuromuscular contractions
- Heart and cardiovascular function
- Regulation of the acid-alkaline balance in the body

Magnesium is necessary for the metabolism of carbohydrates, amino acids and fats; also for energy production, and the utilization of calcium, phosphorus, sodium and potassium which are important electrolytes.

Magnesium Supports:
- Adrenal hormone balance
- Bone health
- Cardiovascular function
- Detoxification functions
- Glucose metabolism
- Mental health
- Nerve function
- Tooth enamel

Magnesium deficiencies have been associated with a variety of conditions such as:

- Confusion
- Occasional sleeplessness
- Low mood states
- Irritability
- Fatigue
- Musculoskeletal conditions
-Tooth decay

 A vegetarian formula of herbal adaptogens to provide basic support for adrenal function.

AdrenaMax by Nutritional Frontiers promotes resilience to stress by supporting the function of the adrenal glands. The herbs in Adrenamax have traditionally been used to help with both hyper-function and hypo-function of the adrenal glands, hence they are classified as ‘adaptogens.

• Cordyceps Mycelium Extract is a medicinal mushroom popular in China and Tibet. Herbalists recommend cordyceps to improve energy, sexual function, athletic performance, and immune function.
• Panax ginseng is also called Chinese ginseng or Asian ginseng, and has been in use since at least the 1st century C.E. Its many constituents, such as ginsenosides and panaxans, contribute to systemic effects such as supporting immune function, lowering blood sugar, improving libido and erectile dysfunction, increasing sperm count, and enhancing physical and intellectual performance.
• • Eleutherococcus senticosus has a variety of applications in the body, such as improving attention, mood, and stress tolerance. People who are debilitated from cancer, chemotherapy, cardiovascular disease, or other chronic health conditions may benefit from this root. Also known as Siberian ginseng, this has been used by herbalists from many countries for at least 2000 years. Eleuthero is stimulating and warming.
• Ashwagandha (Withania somnifera) root is native to Sri Lanka, India, Africa, and Pakistan. A relaxing adaptogen and tonic, this plant is useful for ‘building up’ people who are debilitated from long term stress. Ashwagandha helps in both acute and chronic stress conditions as well as those struggling with insomnia, inflammatory diseases, and anxiety.
• Rhodiola rosea root has been used in Siberia, other parts of the former Soviet Union, Scandinavia, Germany, and other European countries as an adrenal adaptogen with actions similar to Siberian ginseng. Rhodiola may help endurance, cognitive function, immune function, weight management, athletic performance, and energy levels.
• Glycyrrhiza glabra is commonly known as licorice, a plant with a variety of actions in the body. Glycyrrhiza assists with recovery from long term stress by increasing the half life of cortisol. Licorice blocks leukotrienes and therefore possesses anti-inflammatory capabilities. Glycyrrhiza is often used as a demulcent to heal the digestive tract and as an anti-viral and antioxidant. Those with high blood pressure must use caution when ingesting licorice, as it may worsen hypertension in some people.